Anticancer Agents from Natural Products, Second Edition - download pdf or read online

By Gordon M. Cragg,David G. I. Kingston,David J. Newman

ISBN-10: 1439813825

ISBN-13: 9781439813829

The method of drug discovery from ordinary assets has yielded many very important new prescribed drugs inaccessible by way of different routes. in lots of instances the remoted typical product is probably not a good drug for any of numerous purposes, however it however might turn into a drug via chemical amendment or have a singular pharmacophore for destiny drug layout. In summarizing the prestige of typical items as melanoma chemotherapeutics, Anticancer brokers from ordinary items, moment Edition covers the:

  • History of every coated drug—a dialogue of its mechanism on motion, medicinal chemistry, synthesis, and medical applications

  • Potential for novel drug discovery by utilizing genome mining in addition to destiny advancements in anticancer drug discovery

  • Important biosynthetic ways to "unnatural" usual items

Anticancer brokers from normal items, moment Edition discusses how complicated target-oriented synthesis—enabled by means of ancient advances in methodology—has significantly extended the scope of the potential. This booklet covers the present clinically used anticancer brokers which are both typical items or are in actual fact derived from usual product leads. It additionally stories drug applicants presently in medical improvement due to the fact a lot of those should be clinically used medicinal drugs sooner or later.

Examples contain the medication etoposide and teniposide derived from the lead compound podophyllotoxin; quite a few analogs derived from taxol; topotecan, derived from camptothecin; and the artificial scientific applicants, E7389 and HTI-286, built from the marine leads, halichondrin B and hemiasterlin.

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Anticancer Agents from Natural Products, Second Edition by Gordon M. Cragg,David G. I. Kingston,David J. Newman

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